Elucidation of possible mechanisms of the antidiabetic potential of Zn-loaded Bryophyllum pinnatum (Lam.) extracts in experimental animal models

Abstract Background The present study focused on the antidiabetic potential and fingerprinting analysis of Bryophyllumc pinnatum stems as well its possible mechanisms action along with identification major phytoconstituents. oral glucose tolerance test has been performed administering a solution (2000 mg/kg) to induce hyperglycemia. Diabetes have instigated by single intra-peritoneal injection streptozotocin (65 mg/kg). Results Alcohol aqueous extracts were found be safe up dose 3000 mg/kg. Oral results showed significant reduction in fasting blood level. (200, 400 mg/kg b.w.) among all groups. Groups receiving zinc sulfate-loaded statistically low-density lipoproteins, triglycerides total cholesterol levels enhanced high density lipoproteins. Fingerprinting identify phytoconstituents flavonoid category morin, chrysin, 6-hydroxy flavones, iso-quercetin, hyperosides terpenoids possess potential. Conclusions Both alcohol activity diabetic rats. Zinc sulfate synergistically potentiates extract. revealed presence flavonoids such hyperosides, terpenoids. elucidated, although further studies are required give more elaborated mechanism molecular basis. Graphical abstract